Protein Modification Reagents
Medchemexpress LLC Pomalidomide-PEG6-C2-COOH | 2225148-49-0 | 98.95% | C28H39N3O12 | 250 MG
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Pomalidomide-based cereblon ligand and a 6-unit PEG linker, utilized in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates a Pomalidomide-based cereblon ligand.
- Features a 6-unit PEG linker.
- Utilized in PROTAC technology.
Medchemexpress LLC DBCO-mPEG (MW 5kDa) | 99.1% | 100 MG
DBCO-mPEG (MW 5kDa) is a PEG-based PROTAC linker that plays a crucial role in the synthesis of PROTACs. This compound acts as a click chemistry reagent, incorporating a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. PROTACs themselves are engineered with two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, allowing for the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains a DBCO group for SPAAC with azide-containing molecules
- Enables selective degradation of target proteins
Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 25 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs themselves consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for a target protein, and they degrade target proteins by utilizing the intracellular ubiquitin-proteasome system.
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an Azide group for CuAAc reactions
- Participates in SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 1 G
Biotin-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to harness the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a protein of interest.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Facilitates selective degradation of target proteins
- Engages the ubiquitin-proteasome system
Medchemexpress LLC NH-bis(C2-PEG2-NH-Boc) | 2182601-69-8 | 99.9% | 50 MG
NH-bis(C2-PEG2-NH-Boc) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to contain two different ligands connected by a linker, allowing for the exploitation of the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs.
- Functions as a PEG-based PROTAC linker.
- Targets PROTAC linkers and PROTAC pathways.
- Applicable in cancer-programmed cell death.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC DNP-PEG4-NHS ester | 858126-78-0 | 96.81% | C21H28N4O12 | 100 MG
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Stable for 3 years in pure form at -20°C
- Stable for 6 months in solvent at -80°C
- Stable for 1 month in solvent at -20°C
Medchemexpress LLC Dspe-peg-maleimide, mw 5000 | 99.84% | 500 MG
DSPE-PEG-Maleimide, MW 5000, is a linker lipid composed of DSPE phospholipid and Maleimide. It is utilized in the synthesis of various liposomes, including HELDC liposomes, sterically stabilized liposomes, and immunoliposomes. It is for research use only.
- Appearance: Solid
- Color: White to off-white
- Molecular weight: 5000 (average)
- Solubility (In vitro): Soluble in DMSO at 50 mg/mL (requires ultrasonic and warming to 60°C; hygroscopic DMSO significantly impacts solubility)
- Functions as a linker lipid in immunoliposome synthesis
- Can be coupled with thiol-p5314-29 peptide
- Sterically stabilized liposomes containing this product can be coupled with thiolated monoclonal antibody OX26 (OX26-SH)
- HELDC liposomes prepared with 3% of this product show stability in particle size over two weeks, maintaining an average diameter of 120 nm
eMolecules 557756-85-1 | Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 572227290
Fmoc-NH-PEG4-CH2CH2COOH | ChemScene | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 96.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 572227290
Medchemexpress LLC 17-azido-3,6,9,12,15-pentaoxaheptadecyl 4-methylbenzenesulfonate | 906007-10-1 | MFCD29918254 | 98.6% | C19H31N3O8S | 10MG
Azide-PEG6-Tos is an azide-functionalized PEG6 tosylate linker for bioconjugation and PROTAC synthesis. It supplies an azide reactive handle and a tosyl leaving group for downstream functionalization, facilitating click chemistry and linker assembly in small-molecule and bioconjugate research.
- High purity of 98.6% suitable for synthetic applications.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- Tosylate leaving group allows facile nucleophilic substitution and modification.
- PEG6 spacer provides flexibility and improves solubility in polar solvents.
- Liquid form, colorless to light yellow, for easy handling and dosing.
- Stable when stored under recommended conditions to maintain integrity.
- Available in small milligram sizes for discovery and linker development.
Medchemexpress LLC Thp-peg4-pyrrolidine(n-boc)-ch2oh | 2378261-80-2 | 95.0% | 50 MG
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523). It is for research use only. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTAC K-Ras degrader-1
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Dbco-PEG4-VC-PAB-MMAE | 2129164-91-4 | 99.2% | 1658.03 | C88H128N12O19 | 25 MG
DBCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) synthesis and click-chemistry bioconjugation. It combines a DBCO click handle, a PEG4 spacer, a Val-Cit-PAB cleavable linker, and an MMAE cytotoxic payload, and is supplied as a solid powder for laboratory use.
- Contains a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC).
- Includes a hydrophilic PEG4 spacer to improve solubility and reduce aggregation.
- Features a valine-citrulline (Val-Cit) peptide and para-aminobenzyl (PAB) self-immolative linker for enzymatic cleavage.
- Delivers an MMAE warhead suitable for construction of cleavable ADCs.
- Supplied as a white to off-white solid with recommended storage at -20°C and limited stability in solution.
Medchemexpress LLC Dbco-(peg2-vc-pab-mmae)2 | 2259318-55-1 | 99.2% | 2835.50 g·mol⁻¹ | C149H224N22O32 | 10 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a click-chemistry compatible ADC linker dimer that carries monomethyl auristatin E (MMAE) payloads on a cleavable Val-Cit-PAB spacer and features a DBCO handle for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used for bioconjugation and synthesis of antibody-drug conjugates, enabling controlled intracellular release of MMAE via protease cleavage.
- Enables strain-promoted alkyne-azide cycloaddition for copper-free bioconjugation.
- Includes a Val-Cit-PAB protease-cleavable linker for intracellular payload release.
- Delivers MMAE warheads for potent tubulin inhibition after release.
- Available as a powder with multiple package sizes for research-scale synthesis.
- High supplied purity supports reliable conjugation and analytical characterization.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-OH | 2055041-39-7 | MFCD29918232 | 95.0% | 706.78 g·mol⁻¹ | C33H50N6O11 | 25 MG
Mal-PEG4-Val-Cit-PAB-OH is a cleavable four-unit polyethylene glycol (PEG) linker used for the synthesis of antibody-drug conjugates (ADCs). It features a maleimide group for thiol conjugation and a Val-Cit-PAB cleavable spacer that enables intracellular payload release upon proteolysis.
- Cleavable Val-Cit-PAB spacer for protease-triggered payload release.
- Four-unit PEG spacer to increase solubility and reduce aggregation.
- Maleimide functional group for efficient thiol conjugation.
- Designed for antibody-drug conjugate synthesis and research applications.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB | 1949793-41-2 | 98.9% | 777.86 | C36H55N7O12 | 5 MG
Mal-PEG4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker that contains a maleimide reactive group, a four-unit polyethylene glycol (PEG4) spacer, a valine-citrulline (Val-Cit) dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer. It is used in the synthesis of ADCs to enable protease-triggered release of cytotoxic payloads.
- Cleavable linker for protease-triggered payload release.
- Contains maleimide functional group for thiol conjugation.
- PEG4 spacer to improve solubility and reduce aggregation.
- Val-Cit-PAB motif enables self-immolation and controlled payload release.
- High purity (98.9%) and characterized molecular weight 777.86.
- Available in a 5 mg vial for research use.
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eMolecules 1807521-08-9 | TBDMS-PEG5-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | Broadpharm | MFCD28142479 | 508.712 | C23H49N2O6PSi | 98.000 | CC(C)N(C(C)C)P(OCCOCCOCCOCCO[Si](C)(C)C(C)(C)C)OCCC#N | 500mg | 550804124
TBDMS-PEG5-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite | Broadpharm | 1807521-08-9 | MFCD28142479 | 508.712 | C23H49N2O6PSi | 98.000 | CC(C)N(C(C)C)P(OCCOCCOCCOCCO[Si](C)(C)C(C)(C)C)OCCC#N | 500mg | 550804124